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KMID : 0043319910140010035
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Archives of Pharmacal Research
1991 Volume.14 No. 1 p.35 ~ p.40
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Percentages of the Deuterium Retained after para-Hydroxylation of (R)(+)4-2H-Phenytoin and (S)(-)4-2H-Phenytoin in Rat
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Moustafa MA
El-Emam AA/Abdelal AM/Metwally MES
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Abstract
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(R)(+) and (S)(-)4-2H-phenytoin have been used as substrates for the determination of the percentage of deuterium retention (NIH shift) after para-hydroxylation of the substrates in rat. By using GC-MS analyses, the percentages of deuterium retention were found to be 69% and 70% for the (R) and (S) phenyl rings, respectively. The results add additional evidence for the involvement of arene oxide in the oxidation of the pro (R) and pro (S) oxidative enzyme for the pro (S) phenyl and a slow oxidative enzyme for the pro (R) phenyl.
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